Journal article
An Online, Person-Centered, Risk Factor Management Program to Prevent Cognitive Decline: Protocol for A Prospective Behavior-Modification Blinded Endpoint Randomized Controlled Trial
YY Lim, D Ayton, S Perin, A Lavale, N Yassi, R Buckley, C Barton, L Bruns, R Morello, S Pirotta, E Rosenich, SMW Rajaratnam, R Sinnott, A Brodtmann, AI Bush, P Maruff, L Churilov, A Barker, MP Pase
Journal of Alzheimer S Disease | IOS PRESS | Published : 2021
DOI: 10.3233/JAD-210589
Abstract
Background: Several modifiable risk factors for dementia have been identified, although the extent to which their modification leads to improved cognitive outcomes remains unclear. Objective: The primary aim is to test the hypothesis that a behavior modification intervention program targeting personalized risk factors prevents cognitive decline in community-dwelling, middle-aged adults with a family history of dementia. Methods: This is a prospective, risk factor management, blinded endpoint, randomized, controlled trial, where 1510 cognitively normal, community-dwelling adults aged 40-70 years old will be recruited. Participants will be screened for risk factors related to vascular health (..
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Awarded by National Institute on Aging
Funding Acknowledgements
This trial is funded by a National Health and Medical Research (NHMRC) Boosting Dementia Research Initiative grant (GNT1171816). YY Lim is supported by an NHMRC Career Development Fellowship (GNT1162645). D Ayton is supported by an NHMRC Investigator Grant (GNT1195357). M Pase is supported by a Heart Foundation Future Leader Fellowship (GNT102052). R Buckley is supported by a ational Institutes of Health K99R00 award (K99AG061238). Participants will be recruited from the Healthy Brain Project (healthybrainproject.org.au) and from the community. The Healthy Brain Project is managed by YY Lim, M Pase, N Yassi and R Buckley, and is funded by the National Health and Medical Research Council (GNT1158384, GNT1147465, GNT1111603, GNT1105576, GNT1104273), the Alzheimer's Association (AARG-17-591424, AARG-18-591358, AARG-19-643133), the Dementia Australia Research Foundation, the Bethlehem Griffiths ResearchFoundation, the Yulgilbar Alzheimer's Research Program, the National Heart Foundation of Australia (102052), and the Charleston Conference for Alzheimer's Disease.